The misfire is likely a coil pack. Swap them and see if the misfire moves to another cylinder. Fix the crumbling looms at the same time (common problem, easy to fix)
I wouldn't worry about the O2 sensor fix on older XCs (using an anti-fouling plug to move the sensor) - that doesn't seem to happen to the P2s much...if you've got a failed/failing coil pack, fix that first, clear the codes and see if this one returns.
Turbo control Valve is a common failure item, about $90 to replace from IPD, you might just consider doing that upgrade/fix.
Sounds like the car has been well maintained, the items above (coil pack, TCV) are common, but not hard or expensive to fix...
Current Fleet:
2016 Tundra Crewmax 4WD 1794
2005 MB S600 (126K, Michelin AS4, HPL 0W40)
2005 MB SL600 (55K Michelin AS4, Mobil 1 0W40)
2004 V70R (143K, six speed M66, HPL 5W40)
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